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We've turned drug discovery into a search query

Natural products provide the greatest untapped opportunity for drug discovery. We have built the tools to capture it.

Our Platform

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Molecules
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New Medicines

Nature’s chemistry has evolved under billions of years of selective pressure to modulate life’s fundamental phenomena. This has led to incredible diversity of chemical properties and biological activity. This diversity is uncharacteristic of traditional small molecule libraries and inaccessible to even cutting-edge library generation technologies. We’re harnessing this untapped potential to rapidly deliver new medicines, and hope, for complex diseases. Here’s how we do it

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New Modalities

Our chemistry provides a unique opportunity to access known and emerging modalities of tuning biology. We are rapidly identifying novel chemistry that degrades or stabilizes proteins by acting like a molecular glue, changes the shape of difficult-to-drug proteins allowing modulation of an undruggable target, or covalently inhibits specific proteins.

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New Targets

Uncovering the biological basis of the effects of nature’s diverse chemistry is a powerful way to understand the basis of disease. Just as the study of rapamycin once led to the discovery of mTOR signaling, we have built technologies that rapidly uncover novel disease targets while simultaneously advancing these molecules as new medicines. Get in touch to learn more!

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Our Pipeline

Moa

Therapeutic area

Discovery

Optimization

Ind-enabling

Clinical

Undisclosed

Pain


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Multi-Modal

Dermatology

Topical

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Neutrophil Modulator

Immunology & Inflammation

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NLRP3 Pathway

Immunology & Inflammation

Gut-restricted

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Immunology & Inflammation

Systemic

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TGR5

Immunology & Inflammation

Gut-restricted

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Undisclosed (15+)

Undisclosed

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mixture
hits

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Lead
Identification

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Desease
Validation

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Lead
Optimization

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Liver InflaMmation

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2 Chemical Series

Neuroinflammation

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5 Chemical Series

NF-kB / IL-1B signaling

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29 Chemical series

NLRP3 inflammasome

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1 Chemical series

Gut-restricted
fxr agonism

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1 Chemical series

Gut-restricted
tgr5 agonism

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1 Chemical series

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1 Chemical series

PCSK 9

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6 Chemical series

Ind-
enabling

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Indication

Nash, Wilson's disease

Parkinson’s disease, als

Acute liver failure, multiple

Multiple

NASH, PBC, IBD

Type ii diabetes

Pain

Hypercholestrolemia

New Targets

Uncovering the biological basis of the effects of nature’s diverse chemistry is a powerful way to understand the basis of disease itself. Just as the the study of Rapamycin once led to the discovery of mTOR signaling, we have built technologies that rapidly uncover novel disease targets. Get in touch to learn more!

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Our Advantages

Biologically Relevant Library

Shaped by evolution

Unique Technology Platform

Solves well-understood historical challenges of bioactivity annotation, structure elucidation, and manufacturing

>10x greater hit rates

In a head-to-head comparison with multiple difficult targets

Prolific source of next-generation compounds

Molecular glues, and protein-protein interaction disruptors

Compatible across modalities:

Target-binding, target-activity, or phenotypic screening

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